Risk of adenocarcinomas of the esophagus and gastric cardia in patients with gastroesophageal reflux diseases and after antireflux surgery
- W Ye 1, W H Chow , J Lagergren , L Yin , O Nyrén
- W Ye 1, W H Chow , J Lagergren
- 1Department of Medical Epidemiology, Karolinska Institutet, Box 281, SE171 77, Stockholm, Sweden. Weimin.Ye@mep.ki.se
- 0Department of Medical Epidemiology, Karolinska Institutet, Box 281, SE171 77, Stockholm, Sweden. Weimin.Ye@mep.ki.se
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View abstract on PubMed
Summary
This summary is machine-generated.Gastroesophageal reflux significantly increases esophageal and gastric cardia adenocarcinoma risk. Antireflux surgery does not eliminate this elevated cancer risk, highlighting the need for ongoing monitoring.
Area Of Science
- Gastroenterology
- Oncology
- Epidemiology
Background
- Gastroesophageal reflux disease (GERD) is a suspected risk factor for esophageal and gastric cardia adenocarcinoma.
- Prospective data on GERD and cancer risk are limited.
- The impact of antireflux surgery on these cancer risks remains unstudied.
Purpose Of The Study
- To investigate the association between GERD and the risk of esophageal and gastric cardia adenocarcinoma.
- To evaluate the long-term effects of antireflux surgery on upper gastrointestinal cancer development.
Main Methods
- Population-based retrospective cohort study using the Swedish Inpatient Register.
- Inclusion of patients diagnosed with GERD and those who underwent antireflux surgery.
- Nationwide register linkage for follow-up and standardized incidence ratio (SIR) calculation for cancer risk estimation.
Main Results
- GERD strongly correlates with increased risk of esophageal adenocarcinoma (SIR 6.3) and gastric cardia adenocarcinoma (SIR 2.4) in men.
- Esophageal adenocarcinoma risk increased with follow-up time.
- Antireflux surgery did not reduce, and in some cases increased, cancer risk (esophageal adenocarcinoma SIR 14.1, gastric cardia adenocarcinoma SIR 5.3), with risks remaining elevated post-surgery.
Conclusions
- GERD is a significant risk factor for esophageal adenocarcinoma and a moderate risk factor for gastric cardia adenocarcinoma.
- Antireflux surgery does not mitigate the increased risk of these adenocarcinomas.
- Elevated cancer risk persists even after surgical intervention for GERD.
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