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06:34
Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
Published on: April 21, 2011
Physiological migration of hematopoietic stem and progenitor cells
D E Wright1, A J Wagers, A P Gulati
1Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science (New York, N.Y.)
|December 1, 2001
Summary
Hematopoietic stem cells (HSCs) circulate in blood and rapidly migrate. These findings reveal HSCs play a key role in bone marrow reengraftment.
Area of Science:
- Hematology
- Stem Cell Biology
- Immunology
Background:
- Hematopoietic stem cells (HSCs) are primarily found in bone marrow.
- A small population of HSCs is also present in peripheral blood.
Purpose of the Study:
- To investigate the behavior and fate of blood-borne HSCs.
- To understand the physiological role of circulating HSCs.
Main Methods:
- Utilized genetically marked parabiotic mice sharing a common circulation.
- Analyzed HSC engraftment and hematopoiesis after surgical separation.
- Determined the residence time of injected blood-borne progenitor cells.
Main Results:
- Parabionts showed rapid, stable, and functional cross-engraftment of HSCs.
- Partner-derived hematopoiesis was maintained post-separation.
- Circulating HSCs and progenitors have a short residence time in the blood.
Conclusions:
- HSCs actively and continuously migrate through the bloodstream.
- Circulating HSCs are crucial for the functional reengraftment of unconditioned bone marrow.
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