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T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL

A J Leishman1, O V Naidenko, A Attinger

  • 1Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.

Science (New York, N.Y.)
|December 1, 2001
PubMed
Summary

Thymus leukemia antigen (TL), a nonclassical MHC class I molecule, binds CD8alphaalpha instead of CD8alphabeta. This preferential binding influences T cell receptor responses, revealing a new lymphocyte regulation pathway.

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