Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brooke-Spiegler syndrome.

J C Szepietowski1, F Wasik, G Szybejko-Machaj

  • 1Department of Dermatology and Venereology, University of Medicine, Wrocław, Poland. jszepiet@derm.am.wroc.pl

Journal of the European Academy of Dermatology and Venereology : JEADV
|December 4, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suicidal ideation in patients with skin conditions: A multicentre European study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

European Guideline (EuroGuiDerm) on atopic eczema: Living update.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Genetic testing as a tool for diagnosis of congenital stationary night blindness (CSNB) in white spotted breeds in Poland.

Journal of equine veterinary science·2025
Same author

European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

A cross-sectional study on gender differences in body dysmorphic concerns in patients with skin conditions in relation to sociodemographic, clinical and psychological variables.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Chronic nodular prurigo: Association between comorbidities, itch and quality of life.

Journal of the European Academy of Dermatology and Venereology : JEADV·2024

Brooke-Spiegler syndrome, an autosomal dominant condition, presents with cylindromas and trichoepitheliomas. This case highlights their coexistence in one patient, suggesting a shared genetic basis for these related skin tumors.

Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Background:

  • Brooke-Spiegler syndrome is an autosomal dominant disorder.
  • It is characterized by the development of cylindromas, trichoepitheliomas, and spiradenomas.
  • These benign adnexal tumors can manifest differently within affected families.

Observation:

  • A 30-year-old man presented with multiple lesions.
  • He exhibited both trichoepithelioma papulosum multiplex and cylindromas.
  • This represents a rare co-occurrence of these specific tumor types.

Findings:

  • The case demonstrates the simultaneous presence of trichoepithelioma papulosum multiplex and cylindromas in a single individual.
  • This finding supports the concept of a spectrum within Brooke-Spiegler syndrome.

Related Experiment Videos

  • The distinct yet related nature of these tumors suggests shared underlying genetic pathways.

    • Implications:

    • Understanding the relationship between trichoepitheliomas and cylindromas can refine diagnostic criteria for Brooke-Spiegler syndrome.
    • Further research into the genetic underpinnings may reveal novel therapeutic targets.
    • This case emphasizes the importance of comprehensive evaluation for related adnexal tumors in affected individuals.