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Related Experiment Videos

Cognitive subprocesses and schizophrenia. A. Reaction-time decomposition.

S Krieger1, S Lis, B Gallhofer

  • 1Centre for Psychiatry, Justus-Liebig-University Giessen, Germany.

Acta Psychiatrica Scandinavica. Supplementum
|December 4, 2001
PubMed
Summary

Schizophrenia impairs information processing, particularly the selection of responses. While medication helps this specific function, it can slow movement execution in patients.

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Area of Science:

  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Schizophrenia is associated with cognitive deficits, including information processing impairments.
  • Reaction-time (RT) decomposition paradigms offer a method to dissect cognitive processes.

Purpose of the Study:

  • To investigate information processing deficits in schizophrenia using RT decomposition.
  • To determine if specific cognitive subprocesses are affected in schizophrenia.

Main Methods:

  • Employed simple, disjunctive, and choice reaction-time tasks.
  • Decomposed RT into movement latency and movement execution time.
  • Compared drug-naive first-onset, treated first-onset, and chronically ill schizophrenic patients with matched healthy controls.

Main Results:

Related Experiment Videos

  • Schizophrenia primarily affects response-selection subprocesses.
  • Neuroleptic treatment ameliorates response-selection deficits.
  • Neuroleptic treatment is associated with slower movement execution.

Conclusions:

  • Response-selection deficits are selectively observed in first-onset schizophrenic patients.
  • These deficits may be specific to schizophrenia and suggest frontal-posterior disconnection.
  • Impaired response-selection is a key cognitive feature in early schizophrenia.