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Skin prick test in duplicate: is it necessary?

I Devenney1, K Fälth-Magnusson

  • 1Department of Health and Environment, University of Linköping, Sweden.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 4, 2001
PubMed
Summary

Duplicate skin prick testing is generally not recommended for children. This study found that inconsistent results between two tests are rare, suggesting single tests are sufficient and safer.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Dermatology

Background:

  • Duplicate skin prick testing is sometimes recommended due to concerns about false negatives.
  • However, it increases allergen exposure, potentially risking generalized reactions, especially in infants.

Purpose of the Study:

  • To determine if mixed positive/negative results are common in duplicate skin prick tests.
  • To assess if this justifies the practice of duplicate testing.

Main Methods:

  • Retrospective analysis of duplicate skin prick tests.
  • Data collected from a pediatric clinic in Sweden during 1997.

Main Results:

  • Out of 1,087 tests, only 1.3% (14 tests) showed one positive and one negative result.
  • In children under 2 years, this inconsistency occurred in 0.9% (3 of 340 tests).

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Conclusions:

  • The low rate of inconsistent results suggests duplicate testing is unnecessary.
  • Single skin prick tests are likely sufficient for children, minimizing risks associated with increased allergen load.