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Development of infection resistant polyurethane biomaterials using textile dyeing technology
M D Phaneuf1, M J Bide, M Szycher
1Vascular Surgery Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 4, 2001
Summary
This study developed infection-resistant polyurethane biomaterials using textile dyeing technology. The novel method provides sustained antibiotic release, enhancing antimicrobial activity for over 9 days, crucial for clinical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Infectious Disease Research
Background:
- Biomaterial-associated infections are a significant clinical challenge.
- Polyurethane biomaterials require enhanced infection resistance for safe clinical use.
Purpose of the Study:
- To develop a novel infection-resistant polyurethane biomaterial.
- To utilize textile dyeing technology for sustained antibiotic incorporation and release.
Main Methods:
- Synthesized polycarbonate-based urethanes (bdPU, cPU) with different chain extenders.
- Applied fluoroquinolone antibiotic ciprofloxacin (Cipro) using textile dyeing technology.
- Evaluated Cipro release and antimicrobial activity via spectrophotometry and zone of inhibition assays.
Main Results:
- Dyed cPU demonstrated sustained Cipro release and antimicrobial activity for over 9 days, even after aggressive washing.
- Control groups (dyed bdPU, dipped cPU) lost antimicrobial activity within 24 hours.
- Dyed cPU in static solution maintained antimicrobial activity for the full 11-day study period.
Conclusions:
- Textile dyeing technology enables sustained antibiotic release from polyurethane biomaterials.
- This method creates infection-resistant biomaterials with prolonged antimicrobial efficacy.
- The developed cPU-based material shows significant potential for reducing biomaterial-associated infections in clinical settings.