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Updated: Oct 3, 2026

Xenopus laevis as a Model to Identify Translation Impairment
Published on: September 27, 2015
c-Mos and cyclin B/cdc2 connections during Xenopus oocyte maturation
1Centre de Recherche de Biochimie Macromoléculaire, CNRS UPR 1086, Montpellier, France. castro@crbm-cnrs.mop.fr
Abstract:
Fully-grown G2 arrested Xenopus oocytes can be induced to enter and progress into meiotic cell cycle by progesterone stimulation. This process is termed oocyte maturation. An early response to progesterone is the synthesis of the onco-protein c-Mos, defined as the candidate initiator of Xenopus oocyte maturation, which triggers the MAPK cascade, MPF activation and promotes CSF activity. Here we review our current knowledge on the synthesis, activation and functions of c-Mos in connection with MPF activation during maturation. We also discuss our recent results concerning the dispensability of cyclin B degradation in meiosis I-meiosis II transition and the stabilization of c-Mos through its direct phosphorylation by cyclin B/cdc2.
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