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Updated: Oct 3, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
[Chronic colonic pseudo-obstruction secondary to neuroleptics]
S Benlloch1, F Pérez-Aguilar, J Ponce
1Servicio de Medicina Digestiva, Hospital Universitario La Fe, Valencia, Spain.
Abstract:
Colonic pseudo-obstruction is characterized by non-mechanical chronic colonic dilatation. It is an infrequent entity that can be provoked by multiple causes, among them pharmacological. We present the case of a 74-year-old female psychiatric patient who presented abdominal bloating, diarrhea, intense electrolytic alterations and marked radiographic colonic dilatation after treatment with a neuroleptic (zuclopenthixol decanoate). Organic obstruction and other causes were ruled out and the final diagnosis was chronic colonic pseudo-obstruction secondary to the use of neuroleptics. Cisapride (20 mg/8 h) produced a slight improvement in symptoms but colonic dilatation was permanent.
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