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Differentiating clinical profiles: predicting good responders, poor responders, and hyperresponders
1The Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, New York 10021, USA. ikligman@med.cornell.edu
Fertility and Sterility
|December 4, 2001
Summary
Predicting in vitro fertilization (IVF) outcomes involves assessing ovarian reserve markers like follicle-stimulating hormone (FSH) and estradiol. These tests help tailor ovarian stimulation protocols to individual patient needs, improving assisted reproductive technologies (ART) success rates.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization (IVF)
- Assisted Reproductive Technologies (ART)
Background:
- Identifying patient response to ovarian stimulation is crucial for successful IVF.
- Predicting poor, good, and high responders optimizes treatment protocols.
Purpose of the Study:
- To review clinical and laboratory diagnostic methods for predicting IVF patient response.
- To guide the selection of appropriate ovarian stimulation protocols.
Main Methods:
- Analytical review of diagnostic tests for IVF.
- Assessment of clinical and laboratory parameters in women undergoing IVF.
- Correlation of parameters with ovarian stimulation response and ART outcomes.
Main Results:
- Age, basal follicle-stimulating hormone (FSH), estradiol, and inhibin-B levels predict ovarian response.
- Dynamic testing further aids in predicting individual patient response to stimulation.
Conclusions:
- Ovarian reserve markers (e.g., day 3 FSH, inhibin B, estradiol) are key for guiding ART protocol selection.
- No single test guarantees successful IVF outcomes.
- Identifying high responders helps tailor protocols to mitigate risks like ovarian hyperstimulation syndrome (OHSS).