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IL-7-enhanced T-cell response to myelin proteins in multiple sclerosis
E Traggiai1, T Biagioli, E Rosati
1Department Neurological and Psychiatric Sciences, Viale Pieraccini 6, 50134, Florence, Italy. neuroimm@cesit1.unifi.it
Journal of Neuroimmunology
|December 4, 2001
Abstract:
In this study, we investigated the in vitro proliferative response of peripheral blood T lymphocytes from MS patients and controls to MBP and MOG either in the absence or in the presence of the conditioning factor IL-7. In the absence of IL-7, T-cell reactivity to MOG and MBP was similar in MS patients and controls even if an increased MBP response was found in a subgroup of patients with active disease. In the presence of IL-7, increased T-cell reactivity to MBP was observed in MS patients suggesting that their MBP-specific T cells are in a different functional state.