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Consequential late effects in normal tissues.

W Dörr¹, J H Hendry

¹Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, D-01 307 Dresden, Germany.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology

|December 4, 2001

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Aggressive radiation therapy can worsen acute reactions, leading to consequential late effects (CLE). Managing acute responses is key to minimizing these late side effects in sensitive organs like the urinary and intestinal systems.

Area of Science:

Radiation oncology
Radiobiology
Clinical research

Background:

Aggressive irradiation protocols often exacerbate acute reactions.
Recent studies link acute reactions to modulated late effects, termed consequential late effects (CLE).
CLE differs from generic late effects, influenced by factors like dose fractionation and overall treatment time.

Purpose of the Study:

To review preclinical and clinical evidence for consequential late effects (CLE).
To explore the relationship between acute and late radiation effects.
To identify strategies for minimizing late side effects of radiation therapy.

Main Methods:

Literature review of preclinical and clinical studies on CLE.
Analysis of radiobiological parameters differentiating CLE and generic late effects.

Related Experiment Videos

Examination of organ systems exhibiting CLE.

Main Results:

CLE are observed in tissues where acute responses impair barrier function, leading to secondary trauma.
The urinary system, intestinal system, mucosa, and skin are predominantly affected by CLE.
Acute response markers can predict consequential effects.
Dose fractionation and overall treatment time impact acute and CLE similarly, but oppose generic late effects.

Conclusions:

Ameliorating acute radiation responses can effectively minimize CLE.
CLE are a significant consideration in radiation therapy planning for specific organs.
Understanding CLE is crucial for optimizing radiation therapy outcomes and patient safety.