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Contrast agent stability: a continuous B-mode imaging approach.

V Sboros1, C M Moran, S D Pye

  • 1Department of Medical Physics and Medical Engineering, Royal Infirmary, University of Edinburgh, 1 Lauriston Place, Edinburgh EH3 9YW, UK. Vassilis.Sboros@ed.ac.uk

Ultrasound in Medicine & Biology
|December 4, 2001
PubMed
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The stability of ultrasound contrast agents like Definity, Quantison, and Myomap was studied under varying acoustic pressure and dissolved oxygen levels. Definity showed stable backscatter, while Quantison and Myomap performance depended on oxygen concentration and acoustic pressure.

Area of Science:

  • Ultrasound contrast agent research
  • Acoustic physics
  • Biomedical engineering

Background:

  • The stability of ultrasound contrast agents in suspensions with varying dissolved gas levels is not well-documented.
  • Understanding agent behavior under different acoustic pressures and degassing conditions is crucial for accurate imaging.

Purpose of the Study:

  • To investigate the combined effects of acoustic pressure and suspension degassing on the stability and performance of ultrasound contrast agents.
  • To assess the relative performance of Definity, Quantison, and Myomap contrast agents under varied oxygen concentrations.

Main Methods:

  • An in vitro study was conducted using Definity, Quantison, and Myomap contrast agents in suspensions with oxygen partial pressures ranging from 1.5 to 26 kPa.
  • The relative performance was assessed by measuring the decay rate of backscatter echoes under varying acoustic pressure and degassing conditions.

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  • The physical quantity 'overall backscatter' (OB) was defined to quantify agent behavior.

    • Main Results:

    • Quantison and Myomap released free bubbles at high acoustic pressure, which dissolved faster in degassed suspensions.
    • Definity's backscatter decay was independent of the suspension's air content.
    • Bubble destruction was dependent on acoustic pressure, with differing backscatter performance observed for Quantison and Myomap bubble populations.

    Conclusions:

    • The 'overall backscatter' (OB) metric significantly improved the understanding of contrast agent behavior.
    • Single frame insonation is suggested for accurate measurement of tank-representative backscatter, avoiding decay effects from continuous ultrasound fields.
    • Contrast agent stability and performance are significantly influenced by acoustic pressure and dissolved gas levels, with agent-specific responses observed.