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Temporally and spatially restricted expression of the helix-loop-helix transcriptional regulator Id1 during avian

Y Kee1, M Bronner-Fraser

  • 1Division of Biology, 139-74 California Institute of Technology, Pasadena, CA 91125, USA.

Mechanisms of Development
|December 4, 2001
PubMed

Keywords:
Non-programmatic

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...