Regulation of sporulation in Streptomyces coelicolor A3(2): a checkpoint multiplex?

By complementing developmental mutants of Streptomyces coelicolor A3(2), at least 15 regulatory genes for sporulation have been identified and studied at the molecular level, and some of their intracellular interactions have been characterised. Extensive interplay of the regulatory cascade with metabolic, morphological, homeostatic and stress-related checkpoints is emerging.