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Cell cycle control of yeast filamentous growth
1Center for Molecular Oncology, The University of Chicago, Chicago, IL 60637, USA.
Abstract:
Great progress has been made toward dissecting the signal transduction pathways and transcriptional outputs regulating yeast pseudohyphal growth. However, the mechanism underlying polarized morphogenesis in filamentous growth remains unclear. A synthesis of the data suggests that the ultimate target of these pathways is to repress the activity of the mitotic cyclin Clb2 as an antagonist of polarized growth. Here, we discuss how this cell cycle regulation, in concert with control of transcription, ubiquitin-dependent proteolysis and cytoskeletal polarity, may mediate the switch to filamentous growth.
Insights
Yeast pseudohyphal growth involves complex pathways. This study suggests repressing mitotic cyclin Clb2 activity is key to polarized filamentous growth, coordinating cell cycle, transcription, and cytoskeletal changes.
Area of Science:
- Cell Biology
- Microbiology
- Molecular Biology
Background:
- Significant advancements in understanding yeast pseudohyphal growth pathways.
- The precise mechanism of polarized morphogenesis in filamentous growth is not fully understood.
Purpose of the Study:
- To elucidate the mechanism underlying polarized morphogenesis in yeast filamentous growth.
- To discuss how cell cycle regulation, transcription, proteolysis, and cytoskeletal polarity mediate the switch to filamentous growth.
Main Methods:
- Literature synthesis and data interpretation.
- Discussion of existing research on yeast growth regulation.
Main Results:
- A proposed model where signal transduction pathways target the repression of mitotic cyclin Clb2.
- Clb2 acts as an antagonist to polarized growth.
Conclusions:
- Cell cycle regulation, particularly Clb2 repression, is crucial for yeast filamentous growth.
- Coordinated control of transcription, ubiquitin-dependent proteolysis, and cytoskeletal polarity likely mediates the switch to filamentous growth.