Cell cycle control of yeast filamentous growth

Related Experiment Video

Updated: Oct 3, 2026

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
08:13

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

D Rua1, B T Tobe, S J Kron

  • 1Center for Molecular Oncology, The University of Chicago, Chicago, IL 60637, USA.

Current Opinion in Microbiology
|December 4, 2001
PubMed

Insights

Yeast pseudohyphal growth involves complex pathways. This study suggests repressing mitotic cyclin Clb2 activity is key to polarized filamentous growth, coordinating cell cycle, transcription, and cytoskeletal changes.

Area of Science:

  • Cell Biology
  • Microbiology
  • Molecular Biology

Background:

  • Significant advancements in understanding yeast pseudohyphal growth pathways.
  • The precise mechanism of polarized morphogenesis in filamentous growth is not fully understood.

Purpose of the Study:

  • To elucidate the mechanism underlying polarized morphogenesis in yeast filamentous growth.
  • To discuss how cell cycle regulation, transcription, proteolysis, and cytoskeletal polarity mediate the switch to filamentous growth.

Main Methods:

  • Literature synthesis and data interpretation.
  • Discussion of existing research on yeast growth regulation.

Main Results:

  • A proposed model where signal transduction pathways target the repression of mitotic cyclin Clb2.
  • Clb2 acts as an antagonist to polarized growth.

Conclusions:

  • Cell cycle regulation, particularly Clb2 repression, is crucial for yeast filamentous growth.
  • Coordinated control of transcription, ubiquitin-dependent proteolysis, and cytoskeletal polarity likely mediates the switch to filamentous growth.

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