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Septum formation in Aspergillus nidulans.

¹Plant Science Initiative, N234 Beadle Center, University of Nebraska, Lincoln, NE 68588-0660, USA. sharri1@unlnotes.unl.edu

Current Opinion in Microbiology

|December 4, 2001

Summary

Filamentous fungi form septa via a dynamic septal band. This review discusses the assembly and regulation of this fungal cell structure, crucial for hyphal growth.

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Area of Science:

Cell biology
Mycology
Biochemistry

Background:

Filamentous fungi grow as multicellular hyphae separated by septa.
Septum formation in *A. nidulans* involves a dynamic septal band assembled post-mitosis.
This band comprises actin, septins, and formins, and its assembly is regulated by conserved protein kinase cascades.

Purpose of the Study:

To review the dynamics and regulation of septal band assembly in filamentous fungi.
To explore the role of conserved protein kinase cascades in fungal septation.
To discuss potential regulation by cyclin-dependent kinase activity in hyphal differentiation.

Main Methods:

Review of existing literature on fungal septation.
Analysis of molecular components of the septal band (actin, septins, formins).
Discussion of regulatory pathways, including protein kinase cascades and cyclin-dependent kinases.

Main Results:

The septal band is a dynamic structure essential for septum formation in *A. nidulans*.
Assembly of the septal band is dependent on a conserved protein kinase cascade.
Hyphal differentiation may involve regulation of this cascade by cyclin-dependent kinase activity.

Conclusions:

Understanding the dynamics and regulation of the septal band is key to comprehending fungal multicellularity.
Conserved pathways highlight similarities between fungal and yeast septation.
Further research into cyclin-dependent kinase regulation could reveal mechanisms of hyphal differentiation.

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