Realism in drug discovery-could Cassandra be right?

A Diet Enriched in α-Lipoic Acid Reverses the Age-Related Compromise in Antioxidant Defences in Rat Cortical Tissue.

Nutritional neuroscience·2016

Thromboxane A(2) as a possible natural ligand for benzodiazepine receptors.

Neuroscience letters·2009

The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats.

Pharmacopsychiatry·2006

Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial.

Neurology·2005

Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study.

Prostaglandins, leukotrienes, and essential fatty acids·2004

Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats.

Molecular psychiatry·2003

Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data.

Nature biotechnology·2026

Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING.

Nature biotechnology·2026

A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.

Nature biotechnology·2026

High-throughput synthesis of DNA fragments by molecular self-assembly of overlapping oligonucleotides.

Nature biotechnology·2026

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.

Nature biotechnology·2026

Characterization of microbial dark matter at scale with MetaSBT and taxonomy-aware Sequence Bloom Trees.

Nature biotechnology·2026

AI Structural Biology in Nephrology: Powerful Scaffolds, Fragile Certainties.

Journal of the American Society of Nephrology : JASN·2026

Design, synthesis, and preliminary antiproliferative evaluation of azetidine-functionalized pyrrolo[2,3-d]pyrimidines with integrated computational studies.

Journal of biomolecular structure & dynamics·2026

Vibrational Circular Dichroism Spectra of 2,5-Diaminoterephtalate Macrocycles Reveal Distant Vibrational Exciton Coupling.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Bayesian Optimization of a Suzuki Coupling for the Industrial Synthesis of a Sartan Drug Intermediate.

ACS omega·2026

Reversible Coordination Modes in Piperazine-Based Ru(II)-p-Cymene Acylthiourea Complexes: Modulating DNA Groove Binding for Selective Antimelanoma Activity.

ChemMedChem·2026

AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.

Nature communications·2026

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Realism in drug discovery-could Cassandra be right?

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A Diet Enriched in α-Lipoic Acid Reverses the Age-Related Compromise in Antioxidant Defences in Rat Cortical Tissue.

Thromboxane A(2) as a possible natural ligand for benzodiazepine receptors.

The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats.

Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial.

Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study.

Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats.

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Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING.

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Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.

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Design, synthesis, and preliminary antiproliferative evaluation of azetidine-functionalized pyrrolo[2,3-d]pyrimidines with integrated computational studies.

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Bayesian Optimization of a Suzuki Coupling for the Industrial Synthesis of a Sartan Drug Intermediate.

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