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Related Experiment Videos

Linac radiosurgery for skull base meningiomas.

A T Villavicencio1, P M Black, D C Shrieve

  • 1Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115, USA.

Acta Neurochirurgica
|December 4, 2001
PubMed
Summary

Stereotactic radiosurgery effectively controls skull base meningiomas, with 95% of patients showing stable or reduced tumor volume. This treatment offers a low-morbidity option, either alone or with surgery, for these challenging tumors.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Skull base meningiomas pose surgical challenges due to potential morbidity and often present with mild symptoms.
  • Stereotactic radiosurgery is an attractive option for managing these tumors, especially as an adjunct to surgery.

Purpose of the Study:

  • To evaluate local control rates and complications in patients with skull base meningiomas treated with radiosurgery.

Main Methods:

  • 56 patients with skull base meningiomas underwent radiosurgery using a dedicated linear accelerator.
  • Doses ranged from 12-18.5 Gy (mean 15 Gy), conforming to tumor volumes using X-Knife planning.
  • Radiosurgery was used as an adjunct to surgery in 64% of patients and as primary treatment in 36%.

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Main Results:

  • At a median follow-up of 5 years, 95% of patients achieved freedom from progression (tumor growth).
  • Tumor volume decreased in 41% and remained stable in 54% of patients.
  • 9% of patients experienced new or worsened neurologic deficits, indicating a low complication rate.

Conclusions:

  • Linac-based stereotactic radiosurgery is a feasible and effective treatment for skull base meningiomas.
  • It demonstrates high rates of local tumor control with low morbidity, suitable as an adjunct or primary therapy.