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Updated: Aug 14, 2026

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency
Published on: August 6, 2014
Prevalence of mutagens in the environment: experimental data versus simulations
H S Rosenkranz1, A R Cunningham
1Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. rsnkranz@pitt.edu
Abstract:
The recent availability of experimental data on the mutagenicity in Salmonella of a subset of high production volume chemicals allowed a comparison with the estimate derived from computer-based simulations. The prevalence of mutagens in the subsets was not significantly different: 20% versus 19.5% based upon experimental and simulation data, respectively. This provides support for the use of the rapid and low-cost simulation approach.
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