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Age dependent changes in iodine metabolism and thyroid function.

J M Hansen, L Skovsted, K Siersbaek-Nielsen

    Acta Endocrinologica
    |May 1, 1975
    PubMed
    Summary
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    Absolute iodine uptake (AIU) and thyroid hormone levels change with age and sex. AIU declines in both men and women, with females showing lower uptake than males, suggesting age-related changes in thyroid function.

    Area of Science:

    • Endocrinology
    • Gerontology
    • Thyroidology

    Background:

    • Thyroid hormone levels and function are crucial for metabolic regulation.
    • Age and sex are known factors influencing physiological processes, including endocrine function.

    Purpose of the Study:

    • To investigate the age- and sex-related changes in absolute iodine uptake (AIU) and thyroid hormone levels.
    • To assess the relationship between AIU, thyroxine (T4), and triiodothyronine (T3) across different age groups.

    Main Methods:

    • Cross-sectional study involving 48 women and 63 men aged 20-90 years.
    • Measurement of absolute iodine uptake (AIU), serum thyroxine (T4), free T4 index, and serum triiodothyronine (T3).

    Main Results:

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  • AIU significantly decreased with age in both sexes, reaching approximately 60% in older groups compared to younger ones.
  • Females exhibited lower AIU values (about 75% of males).
  • Serum triiodothyronine (T3) decreased with age, while the free T4 index remained unchanged.

    • Conclusions:

    • Advancing age is associated with decreased AIU and T3 levels.
    • The observed changes suggest a potential decrease in T4 and T3 production with aging.
    • Sex differences in AIU warrant further investigation in the context of thyroidal iodine handling.