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Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes.

M Pontoglio1, M Pausa, A Doyen

  • 1Unité des Virus Oncogènes, Centre National de la Recherche Scientifique URA 1644, Département de Biotechnologie, Institut Pasteur, 75724 Paris cedex 15, France. marcop@pasteur.fr

The Journal of Experimental Medicine
|December 26, 2001
PubMed
Summary

Hepatocyte nuclear factor 1-alpha (HNF1alpha) is crucial for producing complement proteins C5 and C8A, essential for the membrane attack complex (MAC) in host defense. Its absence severely impairs complement activity and host defense mechanisms.

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