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[Evaluation of resistance to activated protein C in myocardial infarction patients]

G Avellone1, V Di Garbo, D Di Raimondo

  • 1Istituto di Clinica Medica, Centro per Diagnosi delle Dislipidemie e del Rischio Trombotico, Università degli Studi, Palermo, Italy.

Minerva Cardioangiologica
|December 6, 2001
PubMed

Insights

Resistance to activated protein C (APCR) was found in 30% of men who had myocardial infarction. This finding suggests APCR may play a role in arterial thrombosis and warrants further investigation for prevention strategies.

Area of Science:

  • Hematology
  • Cardiovascular Medicine
  • Genetics

Context:

  • Activated protein C resistance (APCR) is a common inherited coagulation disorder, primarily linked to venous thromboembolism.
  • The association between APCR and arterial thrombosis, particularly myocardial infarction, remains less understood.
  • This study investigates APCR prevalence in male myocardial infarction survivors without traditional cardiovascular risk factors.

Purpose:

  • To determine the prevalence of APCR in men who have experienced myocardial infarction.
  • To assess potential links between APCR and specific coagulation and lipid parameters in these patients.

Summary:

  • Thirty percent of male myocardial infarction patients (n=20) exhibited APCR, compared to none in the control group (n=20).
  • APCR patients showed elevated fibrinogen, LDL-C, APO B100, oxidized LDL antibodies, and C4 levels.
  • Positive correlations were found between the APCR ratio and fibrinogen/oxidized LDL antibodies.

Impact:

  • The high prevalence of APCR in this cohort suggests its potential significance in arterial thrombosis.
  • Findings support considering APCR screening for primary prevention of arterial thrombosis.
  • This research may inform secondary prevention strategies for thromboembolic complications.
Abstract

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