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[Complement: function. Biological significance and clinical aspects (author's transl)].

V Brade

    MMW, Munchener Medizinische Wochenschrift
    |November 16, 1979
    PubMed
    Summary
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    The complement system, a part of innate immunity, involves about twenty serum proteins. Its activation triggers inflammation, cell destruction, and influences immune responses, with deficiencies causing health issues.

    Area of Science:

    • Immunology
    • Biochemistry

    Context:

    • The complement system is a crucial part of the immune system, comprising approximately twenty serum proteins.
    • Complement activation can be initiated by antigen-antibody complexes or via antibody-independent pathways.

    Purpose:

    • To elucidate the biological actions and significance of the complement system in immune responses and host defense.

    Summary:

    • Activated complement proteins mediate critical biological functions, including inflammatory responses, enhanced phagocytosis, and direct lysis of microbial and animal cells.
    • The system significantly influences the immune response to antigenic stimuli.
    • Congenital deficiencies in complement components can severely compromise antimicrobial defense or lead to exaggerated inflammatory reactions.

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    Impact:

    • Understanding complement pathways is vital for comprehending host defense mechanisms and inflammatory processes.
    • Dysregulation of complement activation can have detrimental effects on the organism, highlighting its dual role in health and disease.