Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothalamic region facilitating shivering in rats.

M Tanaka1, M Tonouchi, T Hosono

  • 1Department of Physiology, School of Allied Health Sciences, Osaka University Faculty of Medicine, Suita, 565-0871 Japan.

The Japanese Journal of Physiology
|December 6, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unstable rocker shoes promote recovery from marathon-induced muscle damage in novice runners.

Scandinavian journal of medicine & science in sports·2017
Same author

Motor imagery beyond the motor repertoire: Activity in the primary visual cortex during kinesthetic motor imagery of difficult whole body movements.

Neuroscience·2015
Same author

Fos activation in hypothalamic neurons during cold or warm exposure: projections to periaqueductal gray matter.

Neuroscience·2005
Same author

Thermoregulatory control of sympathetic fibres supplying the rat's tail.

The Journal of physiology·2002
Same author

Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2001
Same author

Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats.

American journal of physiology. Regulatory, integrative and comparative physiology·2001
Same journal

Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?

The Japanese journal of physiology·2006
Same journal

Single-channel properties of volume-sensitive Cl- channel in ClC-3-deficient cardiomyocytes.

The Japanese journal of physiology·2006
Same journal

Synthetic peptides of actin-tropomyosin binding region of troponin I and heat shock protein 20 modulate the relaxation process of skinned preparations of taenia caeci from guinea pig.

The Japanese journal of physiology·2006
Same journal

Establishment of a mouse macula densa cell line with an nNOS promoter driving EGFP expression.

The Japanese journal of physiology·2006
Same journal

The medial amygdala controls the coital access of female rats: a possible involvement of emotional responsiveness.

The Japanese journal of physiology·2006
Same journal

Comparison of biomechanical and histological properties in dog carotid arteries injured by neointima or intimal thickening.

The Japanese journal of physiology·2005
See all related articles

Neurons in the medial hypothalamus regulate shivering. This study found that inhibiting these neurons with muscimol suppressed cold-induced shivering in rats, identifying key thermoregulatory pathways.

Area of Science:

  • Neuroscience
  • Physiology
  • Thermoregulation

Background:

  • The posterior hypothalamus is traditionally linked to thermoregulatory shivering.
  • The precise neural circuits and cell types involved remain unclear.

Purpose of the Study:

  • To investigate the role of hypothalamic neurons in cold-induced shivering.
  • To determine if specific neuronal populations within the medial hypothalamus are essential for shivering.

Main Methods:

  • Urethane-anesthetized rats were exposed to cold (15-21°C) to induce shivering.
  • Muscimol, a GABA(A) receptor agonist, was injected into the medial hypothalamus, targeting dorsomedial and posterior nuclei.

Main Results:

  • Cold exposure successfully elicited shivering in rats.

Related Experiment Videos

  • Injection of muscimol into the medial hypothalamus significantly suppressed cold-induced shivering.

    • Conclusions:

    • Neurons located in the medial hypothalamus, specifically the dorsomedial and posterior nuclei, play a crucial role in initiating and maintaining shivering.
    • These findings suggest the presence of excitatory neurons within this hypothalamic region that drive the shivering thermoregulatory response.