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Deletion 5p11 accompanied by multiple numerical changes in testicular lymphoma
L A Espinoza1, J B Neto, N C Popescu
1Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirãa Preto, São Paulo, Brazil. lae2@georgetown.edu
Cancer Genetics and Cytogenetics
|December 6, 2001
Abstract:
We describe a case of testicular B cell lymphoma with deletion of chromosome 5, del(5)(p11), as a sole structural abnormality. Histopathological diagnosis of the tumor was a high-grade lymphoma of the diffuse type containing cells positive for B cell specific antigen (CD20) and negative for the leukocyte common antigen (CD45). Deletion 5p may define the region of a tumor suppressor gene that could be associated with tumor progression and invasiveness and may serve as an indicator of poor prognosis in testicular lymphomas.