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Related Experiment Videos

A rapid test for sickle hemoglobin.

T Asakura, M E Segal, S Friedman

    JAMA
    |July 14, 1975
    PubMed
    Summary
    This summary is machine-generated.

    A simple shaking test accurately detects sickle hemoglobin (Hb S) by observing precipitation. This method offers a rapid, reliable bedside tool for diagnosing sickle cell disorders.

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    Area of Science:

    • Hematology
    • Biochemistry

    Background:

    • Sickle hemoglobin (Hb S) is an abnormal variant of hemoglobin.
    • Under specific conditions, Hb S can precipitate, leading to sickling disorders.

    Purpose of the Study:

    • To introduce and validate a simple, rapid test for detecting Hb S.
    • To assess the test's accuracy compared to standard electrophoresis.

    Main Methods:

    • Oxygenated sickle hemoglobin (Hb S) solutions were vigorously shaken.
    • The precipitation of Hb S was observed as the primary indicator.
    • Results were compared against cellulose acetate electrophoresis in 599 patient blood samples.

    Main Results:

    • The shaking test demonstrated no false-positive or false-negative results.

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  • The test accurately identified Hb S in individuals with confirmed sickling disorders and unusual hemoglobin patterns.
  • High concordance was observed between the shaking test and electrophoresis.

    • Conclusions:

    • Vigorous shaking of oxygenated Hb S induces precipitation, forming the basis of a novel diagnostic test.
    • This simple precipitation test is a highly accurate and reliable method for detecting Hb S.
    • The test can be rapidly performed in clinical settings, aiding in the prompt diagnosis of sickle cell disorders.