Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Granulocyte function disorders: aspects of development, genetics and management.

K D Yang1, H R Hill

  • 1Chang Gung Children's Hospital at Kaohsiung, Chang Gung University, Kaohsiung 833, Taiwan.

The Pediatric Infectious Disease Journal
|December 6, 2001
PubMed
Summary

Advances in molecular biology and signal transduction have identified genetic defects in phagocytic disorders. Treatments like stem cell transplantation and gene therapy offer potential cures, with prenatal diagnosis enabling early intervention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Association of polycyclic aromatic hydrocarbon exposure and CYP1A1 gene and enzyme activity of peripheral blood monocyte cells in coke oven workers].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2019
Same author

[Effects of bisphenol A on the expression of N-cadherin, Vimentin and FSHR in rat Sertoli cells].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2017
Same author

Loss of B Cells in Patients with Heterozygous Mutations in IKAROS.

The New England journal of medicine·2016
Same author

Predictive factors of persistent infantile atopic dermatitis up to 6 years old in Taiwan: a prospective birth cohort study.

Allergy·2015
Same author

Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2013
Same author

Immune function surveillance: association with rejection, infection and cardiac allograft vasculopathy.

Transplantation proceedings·2012

Area of Science:

  • Immunology
  • Genetics
  • Cell Biology

Background:

  • Phagocytic disorders have gained significant biological and clinical importance over the last 40 years.
  • New molecular biology and signal transduction techniques have enabled the identification of genetic defects in these disorders.

Purpose of the Study:

  • To review the advancements in understanding and treating phagocytic disorders.
  • To highlight the potential of new therapeutic strategies and diagnostic methods.

Main Methods:

  • Utilizing advancements in molecular biology and cellular physiology.
  • Employing immunopharmacologic interventions, stem cell transplantation (bone marrow, peripheral, cord blood), and gene therapy.
  • Implementing carrier detection and prenatal diagnosis using polymerase chain reaction (PCR) and direct nucleotide sequencing.

Related Experiment Videos

Main Results:

  • Genetic defects in various phagocytic disorders have been identified.
  • Therapeutic approaches including stem cell transplantation and gene therapy are being explored to correct defects.
  • Prenatal diagnostic techniques allow for potential in utero or early postnatal treatment.

Conclusions:

  • Phagocytic disorders are increasingly understood at a genetic and cellular level.
  • Innovative treatments offer hope for correcting underlying defects.
  • Early detection and intervention are becoming key to managing these conditions.