Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Smallpox

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

Herpes

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

Chickenpox

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...

Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

Genital Herpes

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pycnogenol enhances endothelial cell antioxidant defenses.

Redox report : communications in free radical research·2016

Same author

Pycnogenol inhibits macrophage oxidative burst, lipoprotein oxidation, and hydroxyl radical-induced DNA damage.

Drug development and industrial pharmacy·2004

Same author

Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract.

The Journal of nutritional biochemistry·2004

Same author

Increased expression of MAIL, a cytokine-associated nuclear protein, in the prodromal stage of black walnut-induced laminitis.

Equine veterinary journal·2004

Same author

A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing.

Annals of the rheumatic diseases·2004

Same author

Slowing of intestinal transit by fat depends on an ondansetron - sensitive, efferent serotonergic pathway.

Neurogastroenterology and motility·2003

Search research articles

Related Experiment Video

Updated: Jul 22, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Herpes zoster during varicella.

B H Lau¹, M I Lin, H C Lin

¹Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. laukawei@kimo.com.tw

The Pediatric Infectious Disease Journal

|December 6, 2001

Summary

A young boy experienced varicella infection followed by herpes zoster in a single thoracic dermatome. This rare co-occurrence of varicella and herpes zoster in a pediatric patient is a unique case report.

More Related Videos

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Related Experiment Videos

Last Updated: Jul 22, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Area of Science:

Pediatrics
Infectious Diseases
Dermatology

Background:

Varicella infection, commonly known as chickenpox, is caused by the varicella-zoster virus (VZV).
Herpes zoster, or shingles, is a reactivation of the VZV, typically occurring later in life.
Dermatomes are specific areas of skin supplied by a single spinal nerve.

Observation:

A 4-year-old boy presented with symptoms of varicella infection.
Two days after the onset of varicella, he developed vesicular lesions localized to the left 10th thoracic dermatome.
Serum analysis confirmed the presence of varicella-zoster virus IgM antibodies.

Findings:

The patient was diagnosed with a concurrent varicella infection and herpes zoster.
This presentation represents a simultaneous occurrence of primary VZV infection and viral reactivation within a specific dermatome.
The localization of herpes zoster lesions to a single thoracic dermatome was noted.

Implications:

This case highlights the potential for unusual presentations of varicella-zoster virus infections in children.
It suggests that VZV reactivation (herpes zoster) can occur concurrently with primary infection (varicella) under certain circumstances.
This finding is significant for understanding the complex pathogenesis of VZV and may inform diagnostic and treatment approaches in pediatric infectious diseases.