Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gene therapy for acute diseases.

P Factor1

  • 1Pulmonary and Critical Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA. pfactor@northwestern.edu

Molecular Therapy : the Journal of the American Society of Gene Therapy
|December 12, 2001
PubMed
Summary

Gene transfer systems offer a novel pharmaceutical approach to restore cell function and treat acute illnesses. This method allows rapid, localized production of therapeutic proteins, potentially reducing side effects and costs associated with traditional treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imaging the spatial distribution of transgene expression in the lungs with positron emission tomography.

Gene therapy·2003
Same author

Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.

Circulation research·2003
Same author

Invited review: lung edema clearance: role of Na(+)-K(+)-ATPase.

Journal of applied physiology (Bethesda, Md. : 1985)·2002
Same author

beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats.

Circulation research·2001
Same author

Role and regulation of lung Na,K-ATPase.

Cellular and molecular biology (Noisy-le-Grand, France)·2001
Same author

GI complications in patients receiving mechanical ventilation.

Chest·2001

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Biotechnology

Background:

  • Gene transfer systems can restore or improve protein function, positively influencing cell function.
  • Overexpression of transgenes can counteract cellular pathophysiology.
  • Gene transfer offers a unique pharmaceutical administration system for rapid biologic response modifier production.

Purpose of the Study:

  • To review recent advances in gene therapy for acute illnesses.
  • To emphasize preclinical models of disease in gene therapy development.
  • To explore the potential of gene therapy for treating various acute and chronic conditions.

Main Methods:

  • Review of preclinical models for gene therapy applications.
  • Analysis of gene transfer vehicle capabilities for transgene product expression.

Related Experiment Videos

  • Focus on the localized delivery and compartmentalized action of gene transfer systems.

    • Main Results:

    • Gene transfer can rapidly affect biologic response modifiers in a compartmentalized manner.
    • This approach may overcome adverse effects and high costs of systemic recombinant pharmaceutical delivery.
    • Preclinical data suggest potential gene therapies for numerous acute and polygenic diseases.

    Conclusions:

    • Gene therapy holds promise for treating acute illnesses by restoring cellular function.
    • Localized gene transfer can provide a safer and more cost-effective alternative to systemic drug delivery.
    • Future applications may include treatments for asthma, cardiovascular events, neurological disorders, and infections.