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Mutagenicity tests with griseofulvin
Mutation Research
|November 1, 1979
Abstract:
Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
Insights
Griseofulvin did not induce chromosomal damage in mice or mutations in bacteria. Control tests with thio-TEPA confirmed the assay
Area of Science:
- Toxicology
- Genetics
- Microbiology
Background:
- Griseofulvin is an antifungal medication.
- Assessing the genotoxicity of pharmaceutical compounds is crucial for public health and safety.
Purpose of the Study:
- To evaluate the potential of griseofulvin to cause genotoxicity.
- To investigate its capacity for inducing chromosomal aberrations and bacterial mutations.
Main Methods:
- Assessing structural chromosomal aberrations in germ and somatic cells of male mice.
- Testing for his+ revertants in Salmonella typhimurium using the Ames test.
- Utilizing thio-TEPA as a positive control for genotoxicity.
Main Results:
- Griseofulvin did not induce significant structural chromosomal aberrations in mouse cells.
- Griseofulvin did not produce his+ revertants in Salmonella typhimurium.
- Positive control thio-TEPA demonstrated significant genotoxic effects, validating the assays.
Conclusions:
- Griseofulvin exhibits no genotoxic potential in the conducted in vivo and in vitro assays.
- The study provides evidence for the safety of griseofulvin concerning genotoxicity.
- The experimental setup was validated by the positive control, ensuring reliable results.