Evaluation of ibuprofen (Motrin). A new antirheumatic agent

Area of Science:

• Pharmacology
• Rheumatology

Background:

• Rheumatoid arthritis and osteoarthritis are common conditions requiring effective symptomatic treatment.
• Aspirin is a widely used agent for these conditions, but can cause gastrointestinal side effects.

Purpose of the Study:

• To evaluate the efficacy and safety of ibuprofen as a mild analgesic for rheumatoid arthritis and osteoarthritis.
• To compare ibuprofen's effects with aspirin, particularly regarding gastrointestinal tolerability.

Main Methods:

• Clinical studies were conducted to assess ibuprofen's effects.
• Comparisons were made between ibuprofen and aspirin in terms of analgesic, anti-inflammatory, and adverse effects.

Main Results:

• Ibuprofen demonstrated comparable analgesic benefits to aspirin for rheumatoid arthritis and osteoarthritis.
• Ibuprofen showed fewer gastrointestinal adverse effects, including occult bleeding, than aspirin.
• The anti-inflammatory effect of ibuprofen at recommended doses was less than that of aspirin.

Conclusions:

• Ibuprofen is a potentially useful analgesic for rheumatoid arthritis and osteoarthritis, especially for patients intolerant to aspirin.
• While effective for pain, its anti-inflammatory and antipyretic uses require further investigation.