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Related Experiment Videos

Brain MR perfusion imaging in humans.

P D Griffiths1, I D Wilkinson, T Wels

  • 1Section of Academic Radiology, University of Sheffield, Sheffield, UK.

Acta Radiologica (Stockholm, Sweden : 1987)
|December 12, 2001
PubMed
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High-concentration gadolinium chelates offer advantages for thin-slice brain MRI. Using 1.0 M gadolinium with 4-mm slices improves signal-to-noise ratio in perfusion imaging.

Area of Science:

  • Radiology and Medical Imaging
  • Neuroimaging
  • Contrast Agent Research

Background:

  • Standard gadolinium chelates are widely used in Magnetic Resonance Imaging (MRI).
  • Optimizing contrast agent concentration and slice thickness is crucial for diagnostic accuracy in brain perfusion imaging.
  • Investigating high-concentration gadolinium agents may enhance image quality and diagnostic yield.

Purpose of the Study:

  • To evaluate the potential benefits of high-concentration gadolinium chelates in thin-slice brain MRI.
  • To compare the efficacy of different concentrations and volumes of gadolinium agents.
  • To assess the impact of slice thickness on perfusion imaging quality.

Main Methods:

  • Thirty-six patients were divided into six groups for perfusion imaging.

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  • Groups received either 7-mm or 4-mm thick slices with varying gadolinium concentrations (0.5 M and 1.0 M) and volumes (10 ml, 20 ml).
  • Time-intensity curves were analyzed for maximum signal reduction and signal-to-noise ratio (SNR).

    • Main Results:

    • Twenty ml of 1.0 M gadolinium significantly increased maximum signal change and SNR compared to 20 ml of 0.5 M gadolinium.
    • No significant difference in maximum signal change was observed between 20 ml of 0.5 M and 10 ml of 1.0 M gadolinium.
    • Slice thickness (7-mm vs. 4-mm) did not significantly affect maximum signal changes with identical dosing regimens.

    Conclusions:

    • Four-millimeter slice thickness perfusion imaging is feasible with high-concentration gadolinium in the human brain.
    • High-concentration gadolinium agents demonstrate advantages in brain perfusion MRI.
    • Further discussion on the benefits of this approach is warranted.