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Benign glandular schwannoma
1Department of Dermatology, Dankook University College of Medicine, 16-5 Anseo-dong, Cheonan, Chungcheong Nam Do 330-714, Korea. kyccc@anseo.dankook.ac.kr
The British Journal of Dermatology
|December 12, 2001
Summary
This study details a rare benign glandular schwannoma on the scalp, a previously unreported location. The findings suggest a potential origin from pluripotential neural crest cells, offering new insights into schwannoma variants.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Pathology
Background:
- Schwannomas are nerve sheath tumors, with glandular schwannoma being a rare subtype.
- The histogenesis of glandular elements within schwannomas remains a subject of debate.
Observation:
- A case of benign glandular schwannoma on the scalp, a novel location, is presented.
- Histological examination revealed a subcutaneous nodule with spindle cells (S-100 positive) and glandular structures (CAM 5.2 and epithelial membrane antigen positive).
Findings:
- Glandular structures did not stain for S-100 protein, arguing against entrapped sweat gland origin.
- Immunohistochemical profile suggests epithelial elements may arise from pluripotential neural crest cells, not direct metaplasia from schwannoma cells.
Implications:
- This case expands the known anatomical distribution of glandular schwannomas.
- The findings contribute to understanding the complex histogenesis of glandular schwannoma, potentially involving neural crest cell differentiation.