Related Experiment Videos
Immune therapy in inflammatory bowel disease and models of colitis
B Singh1, F Powrie, N J Mortensen
1Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK. baljit.singh@nds.ox.ac.uk
Background:
A proliferation of animal models has not only improved our understanding of inflammatory bowel disease, it has also formed the basis of new treatment strategies.
Methods:
A search was conducted using the National Library of Medicine for articles discussing immune therapies for inflammatory bowel disease. This was supplemented by findings from the authors' own laboratory.
Results:
An overview of the different animal models is presented. These models are used to highlight the recent human trials of immune therapies. Potential future therapies are also discussed.
Conclusion:
Immune therapies have altered the management of patients with inflammatory bowel disease. In future they will influence not only the indications for surgery but also its timing and outcome.