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Unusual etiology of visual loss in an HIV-infected patient due to endogenous endophthalmitis
P Miailhes1, M Labetoulle, T Naas
1Department of Internal Medicine, Hôpital Antoine Béclère, Clamart, Department of Hepatogastroenterology, Hôtel-Dieu, 1 place de l'hôpital, 69288 Lyon cedex 2, France. patrick.miailhes@chu-lyon.fr
Abstract:
Disseminated candidiasis, especially ocular infections such as endophthalmitis, is uncommon in HIV-infected patients. We report a case of candidal endophthalmitis in an HIV-positive non-drug-user patient, following candidemia from a cutaneous abscess at the site of a peripheral catheter. Ocular disease was revealed by a visual decrease in the left eye. DNA analysis using RAPD showed identical patterns of Candida albicans isolated from the skin and eye. Combination therapy with high-dose fluconazole and intravenous amphotericin B was performed. Two intravitreal amphotericin B injections and a vitrectomy were administered because of an amblyopic right eye and severe vitritis. The outcome was favorable without relapse at 18 months.
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