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Related Experiment Videos

CD34 expression in desmoplastic melanoma.

M P Hoang1, M A Selim, R C Bentley

  • 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9073, USA. mai.hoang@UTSouthwestern.edu

Journal of Cutaneous Pathology
|December 12, 2001
PubMed
Summary
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Malignant melanoma can mimic dermatofibrosarcoma protuberans (DFSP), even expressing CD34. This case highlights the importance of immunohistochemical analysis for accurate diagnosis of challenging soft tissue tumors.

Area of Science:

  • Oncology
  • Dermatopathology
  • Surgical Pathology

Background:

  • Malignant melanoma can present with diverse histologic features.
  • Metastatic melanoma can mimic various soft tissue neoplasms.
  • Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor characterized by specific cellular morphology and CD34 expression.

Purpose of the Study:

  • To report an unusual case of metastatic malignant melanoma that histologically and immunohistochemically resembled DFSP.
  • To highlight the diagnostic challenges posed by melanoma mimicking other spindle cell tumors.
  • To emphasize the utility of a comprehensive immunohistochemical panel in differentiating challenging neoplasms.

Main Methods:

  • Histopathologic examination of a metastatic melanoma presenting as a soft tissue mass.

Related Experiment Videos

  • Immunohistochemical staining for CD34, S-100 protein, tyrosinase, HMB-45, and MART-1.
  • Electron microscopy to identify melanosomes.

    • Main Results:

    • The tumor exhibited morphologic features closely simulating DFSP, with intersecting fascicles of spindle cells.
    • Neoplastic spindle cells demonstrated strong CD34 expression.
    • Epithelioid components showed positivity for S-100 protein and tyrosinase, with focal melanin pigment.
    • Tumor cells were negative for HMB-45 and MART-1, and melanosomes were absent on electron microscopy.

    Conclusions:

    • Malignant melanoma can exhibit a striking resemblance to DFSP, both morphologically and immunohistochemically.
    • CD34 expression in melanoma, though rare, can occur and contribute to diagnostic confusion.
    • A broad panel of immunohistochemical markers is crucial for accurate diagnosis in cases of suspected soft tissue tumors with ambiguous features.