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Allergy to grape: a case report.

A Rodríguez1, M J Trujillo, V Matheu

  • 1Servicio de Alergia, Sección de Alergia Infantil Hospital, General Universitario Gregorio Marañón, Madrid, Spain. angelrop@hotmail.com

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|December 12, 2001
PubMed
Summary
This summary is machine-generated.

A child experienced oral allergy syndrome and lip swelling after eating grapes. Allergy testing confirmed specific IgE antibodies to a grape protein, validating the diagnosis.

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Area of Science:

  • Food allergy research
  • Clinical immunology

Background:

  • Oral allergy syndrome (OAS) is a common manifestation of food allergies, often linked to pollen-food syndromes.
  • Grape allergy is less common but can cause significant reactions.

Observation:

  • A 5-year-old child presented with lip angioedema and oral allergy symptoms post-grape consumption.
  • Skin prick tests were positive for commercial grape extract and fresh grape components (pulp and peel).

Findings:

  • Immunoblotting identified specific immunoglobulin E (IgE) antibodies in the patient's serum targeting a 94 kDa antigenic band in grape.
  • A lip open challenge confirmed the clinical reactivity to grapes.

Implications:

  • This case highlights a specific grape allergen in a 5-year-old with oral allergy syndrome.
  • Characterizing the 94 kDa allergen could aid in diagnosing and managing grape allergies.