Related Experiment Video

Updated: Oct 3, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating

J Prendiville1, P Thiessen, S B Mallory

  • 1Division of Dermatology, British Columbia's Children's Hospital and University of British Columbia, Vancouver, Canada.

Pediatric Dermatology
|December 12, 2001
PubMed

Insights

Granulocyte colony-stimulating factor (G-CSF) can cause painful skin lesions in children with neutropenia. These neutrophilic dermatoses, including sterile abscesses and panniculitis, may be linked to G-CSF therapy.

Area of Science:

  • Dermatology
  • Pediatrics
  • Hematology

Background:

  • Idiopathic neutropenia is a condition characterized by low neutrophil counts.
  • Granulocyte colony-stimulating factor (G-CSF) is used to treat neutropenia by stimulating neutrophil production.
  • Neutrophilic dermatoses are inflammatory skin conditions characterized by the presence of neutrophils.

Observation:

  • Two children with neutropenia experienced painful skin lesions after receiving G-CSF therapy.
  • A girl with cystic fibrosis and cyclic neutropenia developed an erythematous papular eruption.
  • A boy with chronic neutropenia developed multiple erythematous nodules.

Findings:

  • Skin biopsies revealed sterile neutrophilic abscesses in one child and neutrophilic panniculitis in the other.
  • The skin eruptions occurred in the absence of fever or significant neutrophilia.
  • These findings suggest a link between G-CSF administration and the development of specific skin lesions.

Implications:

  • G-CSF therapy may induce or exacerbate a spectrum of neutrophilic dermatoses.
  • Clinicians should be aware of potential G-CSF-induced cutaneous side effects in pediatric patients.
  • Further research is warranted to understand the mechanisms underlying G-CSF-associated neutrophilic dermatoses.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...