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Contingent negative variation in children with orthostatic dysregulation

K Torigoe1, O Numata, Y Ogawa

  • 1Department of Pediatrics, Nagaoka Red Cross Hospital, Niigata, Japan. torigoe@mail.mynet.ne.jp

Pediatrics International : Official Journal of the Japan Pediatric Society
|December 12, 2001
PubMed

Insights

Children with orthostatic dysregulation (OD) experience hypodynamia due to poor motivation and concentration. Treatment for OD significantly improves these cognitive functions and enhances quality of life.

Area of Science:

  • Neuroscience
  • Pediatrics
  • Psychophysiology

Background:

  • Children with orthostatic dysregulation (OD) often exhibit hypodynamia, impacting motivation, volition, and concentration.
  • These symptoms significantly decrease the quality of life (QOL) in affected children.
  • Contingent Negative Variation (CNV) may reflect attention and motivation levels in children with OD.

Purpose of the Study:

  • To characterize CNV and post-imperative negative variation in children with OD.
  • To assess the relationship between CNV, attention, and motivation in pediatric OD.
  • To evaluate the impact of OD on cognitive functions related to psychophysiological responses.

Main Methods:

  • Compared CNV in 12 children with OD (aged 10-15) and 23 healthy controls.
  • Recorded CNV from Fz, Cz, and Pz sites during a stimulus-response task.
  • Utilized a warning stimulus followed by an imperative stimulus with a 2s interstimulus interval.

Main Results:

  • Untreated children with OD showed no significant difference in CNV amplitude compared to controls.
  • Children with OD treated with midodrine and autonomic training exhibited significantly larger CNV amplitudes.
  • Treatment improved early, late, and total CNV at all recorded sites compared to untreated OD patients.

Conclusions:

  • Confirms diminished motivation and concentration in children with OD, leading to hypodynamia.
  • Treatment for OD effectively improves symptoms, motivation, and concentration, restoring dynamia.
  • Recommends OD treatment to ameliorate QOL in affected children.
Abstract

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