Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary hypertension associated with COPD.

R Naeije1, J A Barberà

  • 1Department of Pathophysiology, Erasme Campus of the Free University of Brussels, Belgium. rnaeije@ulb.ac.be

Critical Care (London, England)
|December 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise pulmonary hypertension in asymptomatic patients with HIV infection Insights from the RIGHT-NET registry.

European journal of internal medicine·2026
Same author

Dual-energy computed tomography (CT) versus cone-beam computed tomography (CT) in chronic thromboembolic pulmonary hypertension: diagnostic accuracy compared with digital subtraction angiography.

Clinical radiology·2025
Same author

Cone beam CT pulmonary angiography in balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension during the program initiation period.

Clinical radiology·2025
Same author

Use of automatic 6-minute walking test recording system in patients with chronic respiratory diseases.

Pulmonology·2023
Same author

Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.

Scientific reports·2022
Same author

Decreased pulmonary vascular distensibility in adolescents conceived by in vitro fertilization.

Human reproduction (Oxford, England)·2019

Pulmonary hypertension in chronic obstructive pulmonary disease (COPD) can cause severe right-sided heart failure. Pathological remodeling, not just hypoxia, drives this condition, suggesting potential benefits from targeted drug therapies.

Area of Science:

  • Cardiology
  • Pulmonology
  • Pathology

Background:

  • Pulmonary hypertension (PH) is a frequent complication of chronic obstructive pulmonary disease (COPD).
  • While often mild, PH in COPD can become severe, leading to right-sided heart failure and worsening respiratory compromise.
  • The underlying pathophysiology involves hypoxic pulmonary vasoconstriction and, increasingly recognized, significant pulmonary arterial remodeling.

Discussion:

  • Recent studies highlight extensive remodeling of pulmonary arterial walls, including intimal changes, as a key factor in COPD-associated PH.
  • This remodeling contributes to the limited reversibility of pulmonary hypertension with supplemental oxygen therapy.
  • The established mechanisms of PH in COPD may not fully explain the severity observed in some patients.

Key Insights:

Related Experiment Videos

  • Pulmonary hypertension in COPD is driven by complex vascular remodeling beyond simple hypoxic vasoconstriction.
  • Severe PH in COPD patients significantly worsens prognosis due to added right ventricular strain.
  • Pharmacological interventions used for primary PH may offer benefits for selected COPD patients.

Outlook:

  • Further research is needed to elucidate the precise mechanisms of pulmonary arterial remodeling in COPD.
  • Clinical trials must address challenges in diagnosing right ventricular failure and defining endpoints for PH in COPD.
  • Targeted therapies like prostacyclin analogs, endothelin antagonists, and inhaled nitric oxide warrant investigation in advanced COPD patients with PH.