Related Experiment Video
Updated: Aug 4, 2026

Mouse Pneumonectomy Model of Compensatory Lung Growth
Published on: December 17, 2014
Implications of post-pneumonectomy compensatory lung growth in pulmonary physiology and disease
L M Brown1, S R Rannels, D E Rannels
1Department of Cellular & Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.
Abstract:
In a number of species, partial pneumonectomy initiates hormonally regulated compensatory growth of the remaining lung lobes that restores normal mass, structure and function. Compensation is qualitatively similar across species, but differs with gender, age and hormonal status. Although the biology of response is best characterized in rats, dogs have proven valuable in defining post-operative physiological adaptations. Most recently, mice were recognized to offer unique opportunities to explore the genetic basis of the response, as well as to evaluate associated detrimental effects of pathophysiological significance in animals exposed to carcinogens. The pneumonectomy model thus offers powerful insight concerning adaptive organ growth.
Related Concept Videos
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Pneumothorax-II
Clinical Manifestations:
Atelectasis II: Pathophysiology
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Pulmonary Edema II: Pathophysiology

