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Chemoreflexsensitivity in chronic heart failure patients.

M G Hennersdorf1, S Hillebrand, C Perings

  • 1Department of Cardiology, Pneumology and Angiology, Medical clinic and policlinic B, Heinrich-Heine-University, Moorenstr. 5, D-40225, Duesseldorf, Germany. hennersdorf@med.uni-duesseldorf.de

European Journal of Heart Failure
|December 12, 2001
PubMed
Summary

Patients with heart failure exhibit reduced hyperoxic chemoreflex sensitivity, linked to a higher incidence of ventricular arrhythmias. This finding may aid in risk stratification for heart failure patients.

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Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function

Background:

  • Heart failure is associated with an imbalanced sympathovagal activity, affecting heart rate variability and baroreflex sensitivity.
  • Ventilatory control is also impaired in heart failure patients, with increased ventilation upon hypoxic gas inhalation.

Purpose of the Study:

  • To investigate whether heart failure patients have diminished hyperoxic chemoreflex sensitivity.
  • To determine if decreased chemoreflex sensitivity correlates with an increased rate of ventricular arrhythmias in heart failure.

Main Methods:

  • Assessed hyperoxic chemoreflex sensitivity by measuring heart rate reduction after pure oxygen inhalation.
  • Calculated chemoreflex sensitivity using the change in RR-interval relative to the change in venous oxygen partial pressure.

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  • Enrolled 49 participants: 23 with heart failure and 26 controls with normal left ventricular ejection fraction.

    • Main Results:

    • Heart failure patients demonstrated significantly lower chemoreflex sensitivity (2.62+/-1.85 ms/mmHg) compared to controls (5.80+/-6.37 ms/mmHg).
    • Nearly 70% of heart failure patients had reduced chemoreflex sensitivity (<3 ms/mmHg), versus 38.5% in the control group.
    • A significant association was found between decreased chemoreflex sensitivity and a higher prevalence of non-sustained ventricular tachycardias (46% vs. 4%).

    Conclusions:

    • Heart failure patients exhibit significantly reduced hyperoxic chemoreflex sensitivity.
    • Diminished chemoreflex sensitivity is linked to an increased occurrence of non-sustained ventricular tachycardias.
    • Chemoreflex sensitivity may serve as a valuable marker for arrhythmic risk stratification in heart failure management.