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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Long-term left ventricular pacing: assessment and comparison with biventricular pacing in patients with severe

A Touiza1, Y Etienne, M Gilard

  • 1Department of Cardiology, Brest University Hospital, Brest, France.

Journal of the American College of Cardiology
|December 12, 2001
PubMed

Insights

Permanent left ventricular (LV) pacing showed a trend toward improvement in severe congestive heart failure (CHF) and left bundle branch block (LBBB) patients. Both LV and biventricular (BiV) pacing offered similar clinical outcomes at six months.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Left ventricular (LV) pacing alone demonstrated acute hemodynamic improvements comparable to biventricular (BiV) pacing in advanced congestive heart failure (CHF) with left bundle branch block (LBBB).
  • Clinical outcomes of permanent LV pacing versus BiV pacing in this patient population remain unevaluated.

Purpose of the Study:

  • To prospectively report six-month follow-up results of permanent LV-based pacing in severe CHF and LBBB patients.
  • To compare the clinical outcomes of LV pacing alone versus BiV pacing.

Main Methods:

  • Thirty-three patients with advanced CHF and LBBB were enrolled.
  • Pacing configuration (LV or BiV) was determined by physician preference.
  • Patient evaluations were conducted at baseline and six-month follow-up.

Main Results:

  • Baseline characteristics were similar between the LV (18 patients) and BiV (15 patients) groups.
  • At six months, no significant difference in New York Heart Association class I or II was observed between groups (p = 0.39).
  • A significant difference was noted in LV end-diastolic diameter decrease, with greater reduction in the BiV group (-4.4 mm) compared to the LV group (-0.7 mm; p = 0.04).

Conclusions:

  • Permanent LV-based pacing showed a trend toward objective parameter improvement in severe CHF and LBBB patients at six months.
  • Both LV and BiV pacing modes resulted in comparable improvements in subjective and objective parameters.
Abstract

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