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Minoxidil effectively controlled severe hypertension in most patients refractory to other drugs. Side effects like fluid retention and hypertrichosis were noted, but renal function often improved.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Severe hypertension often requires multiple agents.
- Refractory hypertension poses significant clinical challenges.
Purpose of the Study:
- To evaluate minoxidil's efficacy in patients with severe, refractory hypertension.
- To assess minoxidil's impact on renal function and identify common side effects.
Main Methods:
- Seventeen patients with refractory hypertension received minoxidil.
- Adjunctive propranolol and diuretics were used to manage side effects.
- Blood pressure, renal function, and adverse events were monitored.
Main Results:
- Excellent initial blood pressure control was achieved in 16 out of 17 patients.
- Eight patients experienced fluid retention, and ten developed hypertrichosis.
- Renal function stabilized or improved in most patients, including those on dialysis.
Conclusions:
- Minoxidil is a valuable therapeutic option for severe, refractory hypertension.
- Careful monitoring for fluid retention and hypertrichosis is essential.
- Minoxidil may benefit renal function in select hypertensive patients.
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