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Acute myocardial infarction. Prognostic value of white blood cell count and blood glucose level

B Modan, S Schor, M Shani

    JAMA
    |July 21, 1975
    PubMed

    Insights

    Higher hospital mortality was observed in acute myocardial infarction (AMI) patients with leukocytosis or high blood glucose. Combining these markers may help identify high-risk AMI patients for immediate coronary care unit admission.

    Area of Science:

    • Cardiology
    • Internal Medicine
    • Biomarkers

    Background:

    • Acute myocardial infarction (AMI) is a leading cause of mortality worldwide.
    • Identifying high-risk patients early is crucial for improving outcomes.
    • Existing risk stratification methods may not fully capture all high-risk individuals.

    Purpose of the Study:

    • To investigate the association between leukocytosis, elevated blood glucose, and hospital mortality in first-time AMI patients.
    • To evaluate the potential of combining these two biomarkers for risk assessment and patient disposition.

    Main Methods:

    • Analysis of data from a nationwide study of patients experiencing their first AMI.
    • Comparison of hospital mortality rates based on the presence or absence of leukocytosis and elevated blood glucose levels.

    Main Results:

    • Patients with leukocytosis or elevated blood glucose, or both, exhibited significantly higher hospital mortality rates.
    • The combined presence of both markers indicated a particularly high risk of in-hospital death.

    Conclusions:

    • Leukocytosis and elevated blood glucose are significant indicators of increased hospital mortality in first AMI.
    • The combination of these simple measurements can serve as a practical diagnostic tool for AMI risk stratification.
    • This combined indicator may guide immediate patient disposition to a coronary care unit for optimal management.

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