Related Experiment Videos
DNA cleavage by aromatic amines
Philip M Warner1, Jiwei Qi, Bin Meng
1Department of Chemistry, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. pwarner@lynx.neu.edu
Bioorganic & Medicinal Chemistry Letters
|December 12, 2001
Abstract:
A series of aryl amines was found to induce cleavage of DNA. Subsequent refinement led to an efficient family of dimeric derivatives capable of cleavage at low concentration. Initial investigations suggest this is an unprecedented mode of DNA cleavage, which may be ultimately applied to the development of sequence-specific agents.