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Synthesis and antinephritic activities of quinoline-3-carboxamides and related compounds
Kiyoshi Tsuji1, Glen W Spears, Katsuya Nakamura
1Medicinal Chemistry Research Laboratories, Fujisawa Pharmaceutical Co., Ltd, 1-6, Kashima 2-chome,Yodogawa-ku, 532-8514, Osaka, Japan. kiyoshi_tsuji@po.fujisawa.co.jp
Bioorganic & Medicinal Chemistry Letters
|December 12, 2001
Abstract:
A series of linomide-related quinoline-3-carboxamides and their analogues was prepared and evaluated for antinephritic activities. The 6-MeS derivative 7a was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.