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Sensitization of hyperthermic treatment of leukemic cell lines by a synthetic peptide
Yasuharu Hori1, Rie Nagai, Naomi Urabe
1Research Institute for Advanced Sciences and Technology, Osaka Prefecture University, 1-2 Gakuen-cho, Sakai, 593-8531, Osaka, Japan.
Bioorganic & Medicinal Chemistry
|December 12, 2001
Abstract:
A compound named HPH-Pep, a peptide constructed from pyridine and histidine units, showed sensitizing effect on the hyperthermic treatment of L-1210, Molt-4, and HL60 cells. The survival rate of these cells was greatly reduced by combined treatment with heating at 44 degrees C and HPH-pep. The treatment of L-1210 and Molt-4 cells with HPH-Pep resulted in a significant breakdown of the survival rate at 44 degrees C. The cell death induced by HPH-Pep under hyperthermic condition seemed to involve iron and peroxide.