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Related Experiment Videos

Olfactory CO(2) chemoreceptors.

E L Coates1

  • 1Department of Biology, Allegheny College, Meadville, PA 16335, USA. lcoates@allegheny.edu

Respiration Physiology
|December 12, 2001
PubMed
Summary
This summary is machine-generated.

Carbon dioxide (CO2)-sensitive olfactory receptors in amphibians and reptiles decrease breathing. This review explores these CO2 receptors in mammals and their potential role in breathing regulation and sudden infant death syndrome (SIDS).

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Area of Science:

  • Comparative physiology
  • Neuroscience
  • Respiratory system

Background:

  • Amphibians and reptiles have CO2-sensitive olfactory receptors affecting breathing.
  • Carbonic anhydrase (CA) inhibition impacts these CO2 olfactory responses in amphibians.
  • Evidence suggests CO2 receptors may exist in mammalian olfactory epithelium.

Purpose of the Study:

  • To review olfactory CO2 receptors in amphibians, reptiles, and mammals.
  • To determine CA activity distribution in rat nasal cavities.
  • To record olfactory receptor responses to CO2 in rats.
  • To discuss the role of olfactory CO2 receptors in breathing control and SIDS.

Main Methods:

  • Literature review of olfactory CO2 receptors.
  • Histological and electrophysiological studies.

Related Experiment Videos

  • Determination of carbonic anhydrase (CA) activity density in rat nasal cavities.
  • Recording olfactory receptor responses to CO2 in specific rat nasal areas.

    • Main Results:

    • CA activity sites correlate with CO2 chemosensitivity in frog olfactory epithelium.
    • Highest CA activity densities were identified in specific regions of the rat nasal cavity.
    • Olfactory receptor responses to CO2 were recorded in these high-CA density areas.

    Conclusions:

    • Olfactory CO2 receptors are present in amphibians, reptiles, and potentially mammals.
    • CA activity serves as a marker for CO2 chemosensitivity.
    • Olfactory CO2 receptors may play a role in respiratory control and conditions like SIDS.